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KMID : 0378019730160010069
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New Medical Journal
1973 Volume.16 No. 1 p.69 ~ p.79
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Studies on the Epidemiology and Clinical Aspects of Clonorchiasis in Korea
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林漢種/Rim, Han Jong
李性均/徐丙卨/Lee, Sung Kyun/Seo, Byong Seol
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Abstract
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Department of Parasitology, College of Medicine Seoul National University
Clonorchiasis is the most important endemic disease in Korea, and this disease has been known to be one of public health concern in many areas of southern part of Korea. During the last fifty years, several surveys on the prevalence among the Korean population have been carried out by various investigators, although the general distribution and prevalences of clonorchiasis are not yet clearly determined.
The present studies have been undertaken to the epidemiological and clinical aspects on the clonor-chiasis in several endemic areas in southern part of Korea. The authors have attempted to use skin test and stool examination.
Fecal specimens were collected from villages including males, females and children in all inhabitants of Bul-Ani 1-Ku, Kim-Hae Eup and Karak Myun, Kim-Hae Gun located in the Delta of Naktong river basin which is one of the most important endemic areas of clonorchiasis. Stool specimens from Chil-Sung Myun, Gue-San Gun were also examined.
The examinations of the feces for eggs of C. sinensis were made by using the cellophane thick smear method and the intensity of the Clonorchis infection was estimated by the Stoll´s egg court. The results are as follow:
1) Among the surveyed area, the prevalence rate of Clonorchis infection was shown as 69.0 per cent in Bul-Am 1-Ku, Kim-Hae Eup, 82.7 per cent in Karak Myun, Kim-Hae Gun, and 62.1 per cent in Chil-Sung Myun, Gue-San Gun.
2) In the highly endemic area, there is no significant difference among the incidences of Clonorchis infection by sex and age.
3) The mean EPG count of Clonorchis infection in the surveyed area was found higher among the higher age group.
4) The degree of the intensity of Clonorchis infection by EPG counts in the surveyed areas was evenly distributed to the medium, heavy and very heavy infection groups in the above 20 years old.
5) The endemicity of C. sinensis in the surveyed area was applied tLe probit analysis and obtained regression equation.
6) The criterion for positive intradermal test was different in each surveyed areas, and also there was observed negative intradermal test in some considerable cases of the light infection group of clonorchiasis.
7) There were observed the higher the intensity of the Clonorchis infection, the higher the leukocytosis and eosinophilia in the blood picture, and also the values of blood biochemistry, i. e. cholesterol, alkaline phosphatase, SGOT, SGPT were elevated by the higher intensity of infection.
8) The detailed clinical symptoms according to the intensity of Clonorchis infection and the correlation
between the period of infection and the intensity of Clonorchis infection were discussed.
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KEYWORD
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